SCIENTIFIC ACTIVITIES

International projects:

1. "Support for further sustainable agriculture and rural development in Turkmenistan" (stage III)

Identification number : № 326114-2016

Project duration : 2017 - 2020

Program or initiative : EUEA

Website : http://iks-company.com/

Project description: Program to support the Government of Turkmenistan and, in particular, the Ministry of Agriculture for Sustainable Development of Agriculture and Rural Areas.

2. "Network of knowledge and innovation on short food supply chains" (SKIN)

Identification number : № 728055

Project duration : 2016 - 2019

Program or initiative : Horizon 2020

Website : http://www.shortfoodchain.eu/

Project description: SKIN is an ambitious initiative in the field of short supply chains (SFSC), which aims to systematize existing knowledge, stimulate innovation based on demand, create long-term cooperation between European farmers and cooperatives, promote stakeholders, attract and encourage research through , bringing producers closer to consumers, encouraging mutual trust to create short chains based on common values for food supply, their origin and method of production. A common base on which a new community is built, characterized by multifaceted (geographical, ethical and cooperative) closeness between food producers and society.

The ultimate goal is to create a permanent stakeholder association that aims to improve the efficiency of short food supply chains for the economic growth of the industry for the benefit of farmers and consumers.

3. "Solutions for optimal vitamin D nutrition and health throughout the life cycle" (ODIN)

Identification number : FP7-613977-ODIN

Project duration : 2014 - 2017

Program or initiative : FP7

Website : http://www.odin-vitd.eu/

Project description: Vitamin D deficiency has serious consequences for human health by affecting normal growth and bone integrity. Lack of knowledge in this area is an obstacle to implementing a safe and effective public health strategy to prevent vitamin D deficiency. The ODIN project will help prevent vitamin D deficiency in Europe and improve nutrition and health through food. Using existing food databases from national surveys , the ODIN project will differentiate between ultraviolet radiation and dietary sources of vitamin D. yeast. The project will investigate the effectiveness and safety of these foods. The aim of the project is - regression analysis to integrate standardized data on vitamin D status, study the relationship between vitamin D and the positive and negative effects on human health during pregnancy, bone growth and body structure in children, allergic and cardiovascular diseases and mortality in adults.

4. "Recovery of food and reduction of waste" ( FoodWard )

Identification number : 09DBAA56F67BD1BC

Project duration : 2014 - 2016

Program or initiative : Erasmus +

Website : http://foodward.mkv-consulting.com/

Project description: The problem of food waste has not been given the necessary attention for a long time, but today, due to the growing level of hunger around the world, it is extremely relevant. By 2050, food demand is likely to increase by 40% to 70%. On the other hand, about a third of food goes to waste (about 1.3 billion tons per year). More than 40% of food losses occur after harvest and processing in developing countries.

This project focuses on the following topics:

• Composite analysis of food waste and losses in Turkey, Italy, Germany and Slovakia
• Quantitative determination of food losses in the milk and meat sector
• Training of production engineers in factories
• Development of consumer consciousness to avoid the growth of food waste
• Reducing food waste and creating a sustainable food future.

5. "European network to reduce bacterial colonization and microbial persistence of opportunistic and pathogenic microorganisms on food and food industry equipment" ( BacFoodNet )

Identification number : COST Action FA1202

Project duration : 2013 - 2016

Program or initiative : FP7

Website : http://www.bacfoodnet.org/EN/Main/

Project description: The aim of this project is to ensure the development of targeted solutions to manage the risks associated with bacterial resistance and the formation of biofilms in the food industry. The project includes experts from various disciplines who will deepen our knowledge of colonization and resistance of bacteria, verification / determination of appropriate methods for monitoring models of established colonies. Study of known and new methods of preventing the formation of biofilms . The acquired knowledge will be applied in the food industry and scientific activity

6. "Strengthening bilateral scientific and technical cooperation with Ukraine * Extended innovation approach" (BILAT-UKR * AINA)

Identification number : 311839

Project duration : 2012 - 2015

Program or initiative: FP7

Project description : The project aims to create a basis for the development of cooperation in the field of research, technological development and innovation (DTI) between the European Union (EU) and Ukraine. It was based on the existing cooperation of key stakeholders and is based on the results of previous FP7-funded projects for Ukraine, in particular BILAT-UKR (2008-2012).

7. "Improving favorable conditions and raising public awareness of innovation in the food sector in South-Eastern Europe through multilateral cooperation" ( Capinfood ).

Identification number : SEE / B / 0027 / 1.3 / X

Project duration : 2011 - 2014

Program or initiative : South East Europe Transnational Cooperation Program

Website : http://www.capinfood.eu/

Project description: The aim of the project is to improve the capacity of institutions that support innovation in the food sector and raise public awareness of the benefits of innovation, facilitate sectoral innovation through international cooperation of national food technology platforms and related institutions. Although the food industry is extremely important for economies, the level of innovation in this area is unsatisfactory, partly due to the unfavorable environment and lack of public support. Barriers to innovation will be removed by task forces in 9 countries. Tools to improve governance (national innovation strategies, industry innovation expert groups, practical guides, ICT solutions) and public awareness tools (information campaigns, virtual forums) will be developed to support institutions. Training courses on food chain management, using ICT solutions in the food sector and knowledge transfer will be provided to key staff. Study tours will be organized for non-EU countries. The forum will be established for transnational cooperation, the work of which is planned after the end of the project. Transnational cooperation aims to improve the level of innovation in countries by transferring experience and pooling knowledge.

8. "Bioactive components in traditional foods"

Identification number : № 227118

Project duration : 2009 - 2012

Program or initiative: FP7

Website : http://www.basefood-fp7.eu/

Project description: Creating a European society based on knowledge of the bioeconomy: by bringing together science, industry and other stakeholders, to use new and emerging research and opportunities, to address social, environmental and economic issues: increasing demand for safer and healthier food , higher quality food and for sustainable production and use of existing traditional and new biological resources. BaSeFood will contribute to the scientific study of the bioactive components of the Black Sea region through analytical and biological tests, in the context of methodological unification and data collection, also taking into account the vast array of traditional food characteristics and potential consumer concerns. health in a receptive context to be properly understood by people and used by stakeholders.

9. Office for Joint Support of Ukraine's Integration into the European Research Area (JSO-ERA)

Identification number : № 227118

Project duration : 2009 - 2011

Program or initiative : FP7

Website : http://www.jso-era.org/ua

Project description: This is a project that raises public awareness of the Seventh Framework Program for Research and Technological Development, assists Ukrainian research organizations in preparing bids.

State funded projects:

1. "Personalized approaches to the diagnosis, prevention and treatment of vascular diseases with prognostic modeling of individual development of atherosclerosis"

State registration number: 0120U102244

Project duration : 2020 - 2022

Program or initiative: Public funding of the project

Project description: the project is aimed at realizing the possibility of effective influence on the incidence of atherosclerosis by personalized correction of epigenetic factors. Selected trigger individual-specific vascular condition biomarkers (Lp-PLA2, PCSK9 and sirtuins SIRT 1, 3, 6), intestinal microbiome indicators and their diagnostic associations associated with different stages of vascular dysfunction and proinflammatory cytokines will be tested in a double-blind , randomized , placebo-controlled cohort study. Prioritization biomarkers will be performed by Data methods Science . The developed methods of prevention and treatment of atherosclerosis will be based on personalized and predictable correction of the microbiome with subsequent reprogramming of the local immune response of the organism. This correction will be carried out with the help of therapeutic nutrition and recommended physical activity, calculated by our algorithm. The prognostic model of individual development of atherosclerosis built with the help of machine learning will be used in the process of treatment.

2. "Introduction of new approaches in the creation and use of modern pharmaceuticals"

State registration number: 0117U000379

Project duration : 2017 - 2019

Program or initiative: Public funding of the project

Project description: a wide preliminary selection of edible plant species of Transcarpathia rich in biologically active substances was carried out. A significant dependence of the BAS content on the peculiarities of the location of plant habitats was revealed. The effect of selected edible plants and microorganisms on the intestinal microbiota was experimentally determined. On the basis of experimental data, the study of pro- and antimicrobial and immunomodulatory properties of promising pre- and probiotic components of pharmabiotics. In experiments in vivo , a search for synergistic effects from the combination of selected pro- and prebiotic components of pharmabiotics was performed. 7 promising combinations were identified, which statistically significantly demonstrate the nonlinearity of the effects of their components on the intestinal microbiome of experimental animals. Microbial and immune markers for trigger states and concomitant and selected NCCs have been refined. A geoinformation system has been created and the selection of plants and microorganisms for personalized correction of the intestinal microbiome has been implemented. Using the bioinformatics methodology developed by us, microbial and immune markers of the microbiome correction process in obesity and type 2 diabetes were determined, and the possibility of controlling the individual course of atherosclerosis was confirmed. The effectiveness of personalized pharmaceuticals for the correction of juvenile depression, atopic dermatitis and ulcerative colitis was tested .

3. "Development of immunobiotics based on lactobacilli for the prevention and treatment of infectious and inflammatory diseases of the genitourinary system"

State registration numbers: 0117U006382, 0118U000905

Project duration : 2017 - 2018

Program or initiative: Public funding of the project (State Fund for Basic Research)

Project description : limited clinical studies have been conducted to confirm the effectiveness of immunobiotics based on lactobacilli with proven anti-inflammatory, immunomodulatory and antimicrobial action for the prevention and treatment of infectious and inflammatory diseases of the genitourinary system in women and men due to different associations of opportunistic microorganisms. Personalized approaches to the prevention and treatment of patients with such combined ( polyetiological ) nosologies have been introduced by taking into account the peculiarities of the microbiome of their urogenital tract and indicators of specific immunoreactivity of the organism. A strategy is proposed that allows you to effectively, individually and selectively (depending on the specific nosology) to use immunobiotics based on different strains of lactobacilli .

4. "Biological disinfectants and prevention of biofilms "

State registration number: 0115U001109

Project duration : 2015 - 2016

Program or initiative: Public funding of the project

Project description : new antibiotics on the basis of selected extracts from edible plants and berries rich in biologically active substances, with proven antibiotic , antimicrobial, anti-inflammatory and immunomodulatory effects and harmless to commensal microbiota of human mucous membranes.

5. "Development of probiotics with antibacterial and immunomodulatory properties based on lacto - and bifidobacteria"

Contract number: 5979

Project duration : 2014 - 2015

Program or initiative : STCU

Project description: the aim of the project is to develop technologies for obtaining the latest biotechnological drugs - probiotics based on pre-selected and characterized strains of lactobacilli (LAB) and / or bifidobacteria, which have antibacterial action and high ability to balance immune response in infectious and inflammatory and bacterial infections. fungal genesis by induction of cytokines of various natures. The aim of this project will be achieved by conducting studies of the specific activity of new combinations of probiotic strains, selection of compositions with the maximum level of induction of balancing cytokines ( interleukin (IL) -4, -10, interferon (IFN) -α), able to reduce proinflammatory activity. cytokines and to balance the imbalance between the Th1 / Th2 immune response in the event of a level of its violation due to infectious disease, conducting preclinical and partially clinical studies of the effectiveness of selected compositions with the following recommendations for their use.

6. "Composite biological products from microorganisms, plants and nanocompounds "

State registration number: 0113U002369

Project duration : 2013 - 2014

Program or initiative: Public funding of the project

Project description : creation of experimental samples of plant-microbial food and medical biological products for the prevention and treatment of food poisoning and non-infectious human pathology caused by impaired metabolism. Objects of research: components of designed composite biological preparations and functional food products of plant origin with associated microorganisms. Purpose: substantiation and proposal of innovative composite biological products and food products with the specified physiological impact on human health for implementation in Ukraine and abroad. Creation of composite drugs. Establishing the compatibility and synergy of all pre-selected components of each of the composite drugs and foods separately. Selection and determination of expediency and efficiency of application of certain natural nanocompounds of plant origin as possible carriers, matrices and capsules for microorganisms in the preparation / product. Completion of preclinical and limited clinical trials, both finished biological products and its main components.

7. "Determining food and bacterial antigens in the prevention of diseases caused by disorders of immune -metabolic processes in the body"

State registration number: 0111U001663

Project duration : 2010 - 2012

Program or initiative: Public funding of the project

Project description : assessment of potential uses in medicine and in the food industry of food antigens (dietary tolerogens ) of plant origin, representatives of the normal microflora of mucous membranes ( commensal and transient ), as well as opportunistic bacteria and their derivatives as structural components of mono and poly- component drugs (functional products) to prevent human diseases caused by immuno -metabolic disorders of the body.

8. "Theoretical foundations, mechanisms of action and use of new biological products and targeted vaccines"

Project duration : 2009 - 2010

Program or initiative : Public funding of the project